Debra Messing

Comedic Cuties

Messing's way with a line on the hit comedy "Will and Grace" and her fiery red locks led many to call her the next Lucille Ball. (Photo by Bryan Bedder/Getty Images for Tribeca Film Festival)

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Mila Kunis "That 70's Show" starlet, Mila Kunis, makes us laugh on TV and on the big screen in "Forgetting Sarah Marshall" and the upcoming "Extract." (Photo by Frazer Harrison/Getty Images)
Cobie Smulders "How I Met Your Mother" star Cobie Smulders is both a Canadian AND a comedic cutie. (Photo by Frederick M. Brown/Getty Images)
Portia de Rossi De Rossi brought both glamour and comedic chops to her role as the self-absorbed Lindsay Bluth on the cult comedy "Arrested Development." (Photo by Frederick M. Brown/Getty Images)
Vivica A. Fox Actress Vivica A. Fox surprised many viewers when she showed she could hold her own alongside funnyman Larry David on his HBO comedy, "Curb Your Enthusiasm." (Photo by Michael Buckner/Getty Images)
Jennifer Garner Girl-next-door Garner showed she could handle tough physical acting in "Alias," but displayed her considerable comedic abilities in the film "13 Going on 30." (Photo by Alberto E. Rodriguez/Getty Images)
Sarah Chalke Her brief run as Becky Conner on "Roseanne" was just the start for this Canadian cutie. She went on to match wits with Zach Braff and Co. on "Scrubs" for eight seasons, and quickly endeared herself to fans in a short guest run on CBS's' "How I Met Your Mother." (Photo by Michael Buckner/Getty Images for AMA)
Katherine Heigl The glamorous "Grey's Anatomy" star showed a real flair for comedy in the big screen hits "Knocked Up" and "27 Dresses." (Photo by Michael Caulfield/Getty Images for PCA)
Jane Krakowski As the ditzy, slightly deranged Jenna Maroney on the NBC comedy "30 Rock," Jane Krakowski delivers spot-on zingers with sex appeal. (Photo by Michael Buckner/Getty Images for IMG
Jenna Fischer As the deadpan Pam on the hit comedy "The Office," Jenna Fischer gets big laughs. (Photo by Ethan Miller/Getty Images)
Emma Stone Rising star Emma Stone impressed critics and audiences with her comedic gifts in "Superbad" and "The House Bunny." (Photo by Stephen Lovekin/Getty Images)
Amy Poehler Poehler singlehandedly made "Saturday Night Live" worth watching during her years on the long-running sketch comedy show. (Photo: Getty Images)
Cameron Diaz Diaz's comedic gifts are evident in films like the smash hit "There's Something About Mary." (Photo by Jason Merritt/Getty Images)
Ana Ortiz The hair, the clothes and the accent provide the humor, and Ortiz brings the charm as Betty's older sister Hilda on ABC's "Ugly Betty." (Photo by Stephen Lovekin/Getty Images)
Kate Hudson Hudson undoubtedly inherited her gift for comedy--and her golden good looks--from her very funny mom, Goldie Hawn. (Photo by Jason Merritt/Getty Images)
Sandra Bullock Superstar Sandra showcased her silly skills and her universal appeal in the blockbuster franchise "Miss Congeniality." (Photo by Michael Buckner/Getty Images)
Tisha Campbell-M... An unsung hero of comedy, Campbell showcased her comedic chops opposite crazy comedian Martin Lawrence on his Fox sitcom, "Martin" and went on to star in "My Wife and Kids." (Photo by Frederick M. Brown/Getty Images)
Vanessa Williams She can pose, she can sing, and she can make us laugh. Williams' Wilhelmina Slater on "Ugly Betty" is a shrewd, conniving businesswoman, and she's good with a line. (Photo by Kristian Dowling/Getty Images)
Chelsea Handler E! talk show host--and hottie--Chelsea Handler straddles the line between fox and funny lady better than most. (Photo by Frederick M. Brown/Getty Images)
Reese Witherspoo... In dark comedies like "Election" and more mainstream films like "Legally Blonde," Witherspoon has showcased her ability to deliver a well-timed zinger. (Photo by Pascal Le Segretain/Getty Images)
Julia Louis-Drey... As the lone female lead on the ensemble comedy "Seinfeld," Louis-Dreyfus more than held her own as sarcastic sidekick Elaine Benes. (Photo by Frederick M. Brown/Getty Images)
Anna Faris Faris is emerging as a comedic leading lady, thanks to starring roles in hilarious hits like "The House Bunny" and "Observe and Report." (Photo by Kristian Dowling/Getty Images)
Lisa Kudrow As part of the acclaimed ensemble sitcom "Friends," Kudrow's portrayal of free-spirited Phoebe--complete with goofy songs--was pure comedic genius. (Photo by Alberto E. Rodriguez/Getty Images)
Jennifer Aniston Her hairdo initially got the bulk of the attention, but Aniston's spot-on portrayal of Rachel Green on "Friends," displayed her great skill for comedy. (Photo by Frederick M. Brown/Getty Images)
Debra Messing Messing's way with a line on the hit comedy "Will and Grace" and her fiery red locks led many to call her the next Lucille Ball. (Photo by Bryan Bedder/Getty Images for Tribeca Film Festival)
Tina Fey With her razor-sharp wit, triple threat actress-producer-writer Tina Fey is the ultimate comedic cutie. (Photo by Frazer Harrison/Getty Images)
Lucille Ball But the original was "I Love Lucy" star Lucille Ball, who made a name for herself (and redheads) with her amazing gift for physical comedy. (Photo by Hulton Archive/Getty Images)
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